Roof Plate Embryology

The cerebellar rhombic lip which forms adjacent to the fourth ventricle roof plate in rhombomere 1 is one of two primary progenitor zones in the developing cerebellum.

Roof plate embryology.

These inductive interactions involve both qualitative and quantitative differences in signaling by tgfbeta related factors and temporal changes in the response of neural progenitor cells. Fate mapping studies have demonstrated that the cerebellar rhombic lip gives rise to cells that populate extra cerebellar regions of the hindbrain including the pontine nuclei machold and fishell 2005. Failure of the secondary palate to develop correctly may result in a cleft palate disorder. The formation and development of the secondary palate occurs through signalling molecules shh bmp 2 fgf 8 among others.

Wang et al 2005. The roof plate of the neural tube responds to those signals by expressing more bmp4 and other transforming growth factor beta tgf β signals to form a dorsal ventral gradient among the neural tube. Roof plate is defined as the lmx1a gdf7 region in both anterior and posterior r1. Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions.

Rose et al 2009. A thinned out trophoblastmembrane over the embryonic disk in developing carnivores and ungulates. It has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous structures in invertebrates such as the fruit fly drosophila and the nematode c. The notochord expresses shh.

The floor plate responds to shh by producing its own shh and forming a gradient. In cattle prevention of the loss of the polar trophoblast layer leads to ectopic domains of brachyury a gastrulation marker. Roof plate cells provide a secondary source of tgfbeta related signals that are required for the generation of distinct classes of dorsal interneurons.